Curiositas

Permanent URI for this collectionhttps://scholarworks.montana.edu/handle/1/16532

Curiositas is an interdisciplinary research journal dedicated to presenting the breadth and depth of undergraduate research that occurs at Montana State University. The journal places a particular emphasis on showcasing overlooked domains of undergraduate research, such as the humanities and arts, alongside traditional scientific research. Curiositas is committed to the belief that research on MSU’s campus does not just occur in large laboratories and research groups: it occurs in every discipline and touches every element of scholarship that occurs at MSU. Articles in Curiositas are reviewed by a faculty member in the appropriate discipline (where applicable) and by an interdisciplinary undergraduate review committee.

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    Bioinformatic Identification of CRISPR Leader Motifs
    (Montana State University, 2021-11) Krishna, Pushya
    Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) and CRISPR associated (Cas) proteins serve as a sophisticated adaptive immune system to defend bacteria and archaea from viral infection. CRISPR mediated immunity occurs in three stages which allow the bacteria to adapt and respond to new as well as previously encountered viruses. The initial step of CRISPR adaptation requires the help of the Integration Host Factor (IHF) and a stretch of 200 base pairs known as the CRISPR leader to ensure encounters with new viruses are properly recorded in the host organism’s immunological memory. A bioinformatic analysis of over 15,000 CRISPR leaders reveals that IHF is a prevalent and widespread feature of CRISPR adaptation across several different CRISPR subtypes and host organisms.
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    The SaeR/S Two Component System: The Security System of Staphylococcus aureus
    (Montana State University, 2021-11) Burroughs, Owen; Voyich, Jovanka
    Staphylococcus aureus (S. aureus) is a common human pathogen that is responsible for thousands of deaths each year. The bacterium’s severity is caused, in part, by its ability to detect and evade the human immune system. In this article, Owen Burroughs, an undergraduate researcher in the lab of Dr. Jovanka Voyich, describes his research into the SaeR/S two-component system, a “security system” that allows S. aureus to avoid being killed by immune cells. Over the course of Owen’s research, the Voyich lab has determined that the proteins SaeP and SaeQ likely play a major role in the functioning of this security system. By helping us better understand the interactions between S. aureus and its host, this research could pave the way for new treatments and therapies for severe S. aureus infection.
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