Center for Biofilm Engineering (CBE)
Permanent URI for this communityhttps://scholarworks.montana.edu/handle/1/9334
At the Center for Biofilm Engineering (CBE), multidisciplinary research teams develop beneficial uses for microbial biofilms and find solutions to industrially relevant biofilm problems. The CBE was established at Montana State University, Bozeman, in 1990 as a National Science Foundation Engineering Research Center. As part of the MSU College of Engineering, the CBE gives students a chance to get a head start on their careers by working on research teams led by world-recognized leaders in the biofilm field.
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Item Strategies for prophylaxis against prosthetic valve endocarditis: a review article(1998-05) Hyde, J. A.; Darouiche, R. O.; Costerton, J. WilliamItem Bacterial biofilms: A common cause of persistent infections(1999-05) Costerton, J. William; Stewart, Philip S.; Greenberg, E. P.Bacteria that attach to surfaces aggregate in a hydrated polymeric matrix of their own synthesis to form biofilms. Formation of these sessile communities and their inherent resistance to antimicrobial agents are at the root of many persistent and chronic bacterial infections. Studies of biofilms have revealed differentiated, structured groups of cells with community properties. Recent advances in our understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.Item Biofilm formation by porphyromonas gingivalis and streptococcus gordonii(1998) Cook, Guy S.; Costerton, J. William; Lamont, Richard J.Confocal scanning laser microscopy (CSLM) was used to visualize and quantify biofilm formation by the oral bacteria Streptococcus gordonii and Porphyromonas gingivalis, A saliva-coated glass coverslip under continuous bacterial challenge and conditions of low shear force was used to investigate attachment to the salivary pellicle and also the effect of cell-cell interactions on the extent of colonization and biofilm development. S. gordonii bound to the salivary pellicle and outcompeted P. gingivalis for attachment sites. Both P. gingivalis and S. gordonii failed to establish substantial biofilm formation independently. However, biofilm formation did occur subsequent to initial adherence of P. gingivalis to S. gordonii cells deposited on the salivary pellicle. The commensal species S. gordonii may. therefore, provide an attachment substrate for colonization and biofilm accretion by the potential pathogen, P. gingivalis.Item The involvement of cell-to-cell signals in the development of a bacterial biofilm(1998-04) Davies, David Gwilym; Parsek, Matthew R.; Pearson, J.; Iglewski, Barbara H.; Costerton, J. William; Greenberg, E. P.Bacteria in nature often exist as sessile communities called biofilms. These communities develop structures that are morphologically and physiologically differentiated from free-living bacteria. A cell-to-cell signal is involved in the development of Pseudomonas aeruginosa biofilms. A specific signaling mutant, alasI mutant, forms flat, undifferentiated biofilms that unlike wild-type biofilms are sensitive to the biocide sodium dodecyl sulfate. Mutant biofilms appeared normal when grown in the presence of a synthetic signal molecule. The involvement of an intercellular signal molecule in the development of P. aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aeruginosa biofilms are a persistent problem.Item Biofilms in the new millennium: musing from a peak in Xanadu(2000) Costerton, J. WilliamItem Enhanced bacterial biofilm control using electromagnetic fields in combination with antibiotics(1999) McLeod, Bruce R.; Fortun, Susana M.; Costerton, J. William; Stewart, Philip S.Item The biofilm lifestyle(1997-04) Costerton, J. William; Lewandowski, ZbigniewItem Bacterial doubling time modulates the effects of opsonisation and available iron upon interactions between staphylococcus aureus and human neutrophils(1996-12) Domingue, Gill; Costerton, J. William; Brown, Michael R. W.Staphylococcus aureus was grown exponentially at two doubling times (DT), one related to in vivo (DT 60 min) and one typical of laboratory conditions (DT 24 min), and under iron-poor and iron-rich conditions. Relative to the fast-grown phenotypes, both slow-grown phenotypes exhibited low surface hydrophobicity and low protein A expression, induced poorly in non-opsonised and opsonised chemiluminescence, and survived well in whole blood killing. In particular, slow-grown, iron-poor cocci demonstrated enhanced survival in whole blood killing which correlated with a significant reduction in their association with polymorphonuclear leukocytes, compared to the three other phenotypes; iron sufficiency increased the ability to stimulate polymorphonuclear leukocytes irrespective of opsonisation status. Staphylococcal DT may, by influencing surface hydrophobicity, modify interactions with immune system components.Item Morphological and metabolic responses to starvation by the dissimilatory metal-reducing bacterium Shewanella alga bry(1996-12) Caccavo, Frank; Ramsing, N. B.; Costerton, J. WilliamItem Cross-training for engineers and scientists(1996) Costerton, J. William; Sears, N.