Core Protein-Directed Antivirals and Importin β Can Synergistically Disrupt Hepatitis B Virus Capsids

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dc.contributor.authorKim, Christine
dc.contributor.authorBarnes, Lauren F.
dc.contributor.authorSchlicksup, Christopher J.
dc.contributor.authorPatterson, Angela J.
dc.contributor.authorBothner, Brian
dc.contributor.authorJarrold, Martin F.
dc.contributor.authorWang, Che-Yen Joseph
dc.contributor.authorZlotnick, Adam
dc.date.accessioned2022-09-26T14:52:17Z
dc.date.available2022-09-26T14:52:17Z
dc.date.issued2022-01
dc.description.abstractThe HBV core, an icosahedral complex of 120 copies of the homodimeric core (capsid) protein with or without packaged nucleic acid, is transported to the host nucleus by its interaction with host importin proteins. Importin-core interaction requires the core protein C-terminal domain, which is inside the capsid, to “flip” to the capsid exterior.en_US
dc.identifier.citationKim, Christine, Lauren F. Barnes, Christopher J. Schlicksup, Angela J. Patterson, Brian Bothner, Martin F. Jarrold, Che-Yen Joseph Wang, and Adam Zlotnick. "Core Protein-Directed Antivirals and Importin β Can Synergistically Disrupt Hepatitis B Virus Capsids." Journal of virology 96, no. 2 (2022): e01395-21.en_US
dc.identifier.issn0022-538X
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/17223
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.rightscopyright American Society for Microbiology 2022en_US
dc.rights.urihttps://web.archive.org/web/20181013000300/https://journals.asm.org/content/statement-author-rightsen_US
dc.subjectHBVen_US
dc.subjectantiviralen_US
dc.subjectassemblyen_US
dc.subjectcapsiden_US
dc.subjectkaryopherinen_US
dc.titleCore Protein-Directed Antivirals and Importin β Can Synergistically Disrupt Hepatitis B Virus Capsidsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage19en_US
mus.citation.issue2en_US
mus.citation.journaltitleJournal of Virologyen_US
mus.citation.volume96en_US
mus.data.thumbpage10en_US
mus.identifier.doi10.1128/JVI.01395-21en_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.universityMontana State University - Bozemanen_US

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