Effect of model selection on prediction of periodic behavior in gene regulatory networks

dc.contributor.authorGedeon, Tomas
dc.contributor.authorCummins, G.
dc.contributor.authorHeys, Jeffrey J.
dc.date.accessioned2016-02-08T18:28:16Z
dc.date.available2016-02-08T18:28:16Z
dc.date.issued2012-08
dc.description.abstractOne of the current challenges for cell biology is understanding of the system level cellular behavior from the knowledge of a network of the individual subcellular agents. We address a question of how the model selection affects the predicted dynamic behavior of a gene network. In particular, for a fixed network structure, we compare protein-only models with models in which each transcriptional activation is represented both by mRNA and protein concentrations. We compare linear behavior near equilibria for both cyclic feedback systems and a general system. We show that, in general, explicit inclusion of the mRNA in the model weakens the stability of equilibria. We also study numerically dynamics of a particular gene network and show significant differences in global dynamics between the two types of models.en_US
dc.identifier.citationT. Gedeon, G. Cummins, and J. J. Heys, “Effect of Model Selection on Prediction of Periodic Behavior in Gene Regulatory Networks,” Bull Math Biol, vol. 74, no. 8, pp. 1706–1726, May 2012.en_US
dc.identifier.issn0092-8240
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/9543
dc.titleEffect of model selection on prediction of periodic behavior in gene regulatory networksen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1706en_US
mus.citation.extentlastpage1726en_US
mus.citation.issue8en_US
mus.citation.journaltitleBulletin of Mathematical Biologyen_US
mus.citation.volume74en_US
mus.contributor.orcidGedeon, Tomas|0000-0001-5555-6741en_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.categoryPhysics & Mathematicsen_US
mus.identifier.doi10.1007/s11538-012-9732-2en_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentMathematical Sciences.en_US
mus.relation.universityMontana State University - Bozemanen_US

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