Structure guided generation of thieno[3,2-d]pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors

Loading...
Thumbnail Image

Date

2021-01

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

Screening for inhibitors of Cyt-bd in Mycobacterium bovis BCG and Mycobacterium tuberculosis revealed thieno[3,2-d]pyrimidine (7) which through SAR efforts resulted in an improved analogue (19) of this scaffold.

Description

Keywords

thieno amine inhibitors

Citation

Hopfner, S. M., Lee, B. S., Kalia, N. P., Miller, M. J., Pethe, K., & Moraski, G. C. (2021). Structure guided generation of thieno [3, 2-d] pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors. RSC medicinal chemistry, 12(1), 73-77.
Copyright (c) 2002-2022, LYRASIS. All rights reserved.