RNAi and Antiviral Defense in the Honey Bee

dc.contributor.authorBrutscher, Laura M.
dc.contributor.authorFlenniken, Michelle L.
dc.date.accessioned2016-07-28T18:17:15Z
dc.date.available2016-07-28T18:17:15Z
dc.date.issued2015-12
dc.description.abstractHoney bees play an important agricultural and ecological role as pollinators of numerous agricultural crops and other plant species. Therefore, investigating the factors associated with high annual losses of honey bee colonies in the US is an important and active area of research. Pathogen incidence and abundance correlate with Colony Collapse Disorder- (CCD-) affected colonies in the US and colony losses in the US and in some European countries. Honey bees are readily infected by single-stranded positive sense RNA viruses. Largely dependent on the host immune response, virus infections can either remain asymptomatic or result in deformities, paralysis, or death of adults or larvae. RNA interference (RNAi) is an important antiviral defense mechanism in insects, including honey bees. Herein, we review the role of RNAi in honey bee antiviral defense and highlight some parallels between insect and mammalian immune systems. A more thorough understanding of the role of pathogens on honey bee health and the immune mechanisms bees utilize to combat infectious agents may lead to the development of strategies that enhance honey bee health and result in the discovery of additional mechanisms of immunity in metazoans.en_US
dc.description.sponsorshipNational Institutes of Health IDeA Program COBRE Grant GM110732; National Science Foundation EPSCoR NSF-IIA-1443108;en_US
dc.identifier.citationBrutscher, Laura M. , Michelle L. Flenniken, and . "RNAi and Antiviral Defense in the Honey Bee." Journal of Immunology Research 2015 (December 2015 ): 10 pages . DOI: 10.1155/2015/941897.en_US
dc.identifier.issn2314-8861
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/9944
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcodeen_US
dc.titleRNAi and Antiviral Defense in the Honey Beeen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage10en_US
mus.citation.journaltitleJournal of Immunology Researchen_US
mus.citation.volume2015en_US
mus.contributor.orcidFlenniken, Michelle L.|0000-0003-0356-3370en_US
mus.data.thumbpage2en_US
mus.identifier.categoryChemical & Material Sciencesen_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.1155/2015/941897en_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.departmentPlant Sciences & Plant Pathology.en_US
mus.relation.researchgroupMontana Institute on Ecosystems.en_US
mus.relation.universityMontana State University - Bozemanen_US

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