Standardized reactors for the study of medical biofilms: a review of the principles and latest modifications

dc.contributor.authorGomes, I. B.
dc.contributor.authorMeireles, A.
dc.contributor.authorGoncalves, A. L.
dc.contributor.authorGoeres, Darla M.
dc.contributor.authorSjollema, J.
dc.contributor.authorSimoes, L. C.
dc.contributor.authorSimoes, M.
dc.date.accessioned2018-01-18T18:53:39Z
dc.date.available2018-01-18T18:53:39Z
dc.date.issued2017-09
dc.description.abstractBiofilms can cause severe problems to human health due to the high tolerance to antimicrobials; consequently, biofilm science and technology constitutes an important research field. Growing a relevant biofilm in the laboratory provides insights into the basic understanding of the biofilm life cycle including responses to antibiotic therapies. Therefore, the selection of an appropriate biofilm reactor is a critical decision, necessary to obtain reproducible and reliable in vitro results. A reactor should be chosen based upon the study goals and a balance between the pros and cons associated with its use and operational conditions that are as similar as possible to the clinical setting. However, standardization in biofilm studies is rare. This review will focus on the four reactors (Calgary biofilm device, Center for Disease Control biofilm reactor, drip flow biofilm reactor, and rotating disk reactor) approved by a standard setting organization (ASTM International) for biofilm experiments and how researchers have modified these standardized reactors and associated protocols to improve the study and understanding of medical biofilms.en_US
dc.identifier.citationGomes I.B., A. Meireles , A.L. Gonçalves, D.M. Goeres, J. Sjollema, L. C. Simões, M. Simões, "Standardized reactors for the study of medical biofilms: a review of the principles and latest modifications," Critical Reviews in Biotechnology (September 2017): 1-14. doi: 10.1080/07388551.2017.1380601.en_US
dc.identifier.issn0738-8551
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/14163
dc.titleStandardized reactors for the study of medical biofilms: a review of the principles and latest modificationsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage14en_US
mus.citation.journaltitleCritical Reviews in Biotechnologyen_US
mus.data.thumbpage7en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1080/07388551.2017.1380601en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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