Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers

dc.contributor.authorThompson, Matthew A.
dc.contributor.authorMartin, Stephen A.
dc.contributor.authorHislop, Brady D.
dc.contributor.authorYounkin, Roubie
dc.contributor.authorAndrews, Tara M.
dc.contributor.authorMiller, Kaleena
dc.contributor.authorJune, Ronald K.
dc.contributor.authorAdams, Erik S.
dc.date.accessioned2023-02-23T18:57:40Z
dc.date.available2023-02-23T18:57:40Z
dc.date.issued2023-01
dc.description.abstractBackground. Agricultural workers have a higher incidence of osteoarthritis (OA), but the etiology behind this phenomenon is unclear. Calving season, which occurs in mid- to late-winter for ranchers, includes physical conditions that may elevate OA risk. Our primary aim was to determine whether OA biomarkers are elevated at the peak of calving season compared to pre-season, and to compare these data with joint health survey information from the subjects. Our secondary aim was to detect biomarker differences between male and female ranchers. Methods. During collection periods before and during calving season, male (n = 28) and female (n = 10) ranchers completed joint health surveys and provided samples of blood, urine, and saliva for biomarker analysis. Statistical analyses examined associations between mean biomarker levels and survey predictors. Ensemble cluster analysis identified groups having unique biomarker profiles. Results. The number of calvings performed by each rancher positively correlated with plasma IL-6, serum hyaluronic acid (HA) and urinary CTX-I. Thiobarbituric acid reactive substances (TBARS), a marker of oxidative stress, was significantly higher during calving season than pre-season and was also correlated with ranchers having more months per year of joint pain. We found evidence of sexual dimorphism in the biomarkers among the ranchers, with leptin being elevated and matrix metalloproteinase-3 diminished in female ranchers. The opposite was detected in males. WOMAC score was positively associated with multiple biomarkers: IL-6, IL-2, HA, leptin, C2C, asymmetric dimethylarginine, and CTX-I. These biomarkers represent enzymatic degradation, inflammation, products of joint destruction, and OA severity. Conclusions. The positive association between number of calvings performed by each rancher (workload) and both inflammatory and joint tissue catabolism biomarkers establishes that calving season is a risk factor for OA in Montana ranchers. Consistent with the literature, we found important sex differences in OA biomarkers, with female ranchers showing elevated leptin, whereas males showed elevated MMP-3.en_US
dc.identifier.citationThompson, M.A., Martin, S.A., Hislop, B.D. et al. Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers. BMC Musculoskelet Disord 24, 80 (2023). https://doi.org/10.1186/s12891-022-05979-2en_US
dc.identifier.issn1471-2474
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/17730
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.rightscc-byen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectBiomarkersen_US
dc.subjectOsteoarthritisen_US
dc.subjectSex differencesen_US
dc.subjectInflammationen_US
dc.subjectJoint painen_US
dc.subjectRanchingen_US
dc.subjectCalving seasonen_US
dc.titleSex-specific effects of calving season on joint health and biomarkers in Montana ranchersen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage15en_US
mus.citation.issue1en_US
mus.citation.journaltitleBMC Musculoskeletal Disordersen_US
mus.citation.volume24en_US
mus.data.thumbpage7en_US
mus.identifier.doi10.1186/s12891-022-05979-2en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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