A 3D model of antimicrobial action on biofilms

dc.contributor.authorHunt, Stephen Michael
dc.contributor.authorHamilton, Martin A.
dc.contributor.authorStewart, Philip S.
dc.date.accessioned2017-07-13T22:38:53Z
dc.date.available2017-07-13T22:38:53Z
dc.date.issued2005
dc.description.abstractA three-dimensional cellular automata model of biofilm dynamics was adapted to simulate the protection from killing by antimicrobial agents afforded to microorganisms in the biofilm state. The model incorporated diffusion and simultaneous utilization of a single substrate, growth and displacement of cells, detachment, and killing by an antimicrobial agent. The rate of killing was assumed to be directly proportional to the local concentration of substrate available to the microorganisms. Some of the features predicted by this model included development of dynamic, heterogeneous biofilm structures, gradients in substrate concentration leading to regions of substrate depletion in the interior of large cell clusters, variable killing by an antimicrobial agent from one simulation to the next, greater killing of cells at the periphery of cell clusters compared to those cells which were more deeply embedded, and reduced overall antimicrobial susceptibility of cells in the biofilm. These simulations show that substrate limitation can contribute to the protection from antimicrobial agents in biofilms but cannot explain the long-term persistence of biofilm viability that is often observed in practice.en_US
dc.identifier.citationHunt SM, Hamilton MA, Stewart PS, "A 3D model of antimicrobial action on biofilms," Water Sci Technol, 2005 52(7):143-148en_US
dc.identifier.issn0273-1223
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/13309
dc.titleA 3D model of antimicrobial action on biofilmsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage143en_US
mus.citation.extentlastpage148en_US
mus.citation.issue7en_US
mus.citation.journaltitleWater Science & Technologyen_US
mus.citation.volume52en_US
mus.contributor.orcidStewart, Philip S.|0000-0001-7773-8570en_US
mus.data.thumbpage3en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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