College of Letters & Science

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The College of Letters and Science, the largest center for learning, teaching and research at Montana State University, offers students an excellent liberal arts and sciences education in nearly 50 majors, 25 minors and over 25 graduate degrees within the four areas of the humanities, natural sciences, mathematics and social sciences.

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Author: search.filters.author.Barnes, Lauren F.Subject: search.filters.subject.antiviral

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    Core Protein-Directed Antivirals and Importin β Can Synergistically Disrupt Hepatitis B Virus Capsids
    (American Society for Microbiology, 2022-01) Kim, Christine; Barnes, Lauren F.; Schlicksup, Christopher J.; Patterson, Angela J.; Bothner, Brian; Jarrold, Martin F.; Wang, Che-Yen Joseph; Zlotnick, Adam
    The HBV core, an icosahedral complex of 120 copies of the homodimeric core (capsid) protein with or without packaged nucleic acid, is transported to the host nucleus by its interaction with host importin proteins. Importin-core interaction requires the core protein C-terminal domain, which is inside the capsid, to “flip” to the capsid exterior.
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