Quorum sensing inhibition as a promising method to control biofilm growth in metalworking fluids

dc.contributor.authorOzcan, Safiye S.
dc.contributor.authorDieser, Markus
dc.contributor.authorParker, Albert E.
dc.contributor.authorBalasubramanian, Narayanaganesh
dc.contributor.authorForeman, Christine M.
dc.date.accessioned2019-07-03T17:38:43Z
dc.date.available2019-07-03T17:38:43Z
dc.date.issued2019-04
dc.description.abstractMicrobial contamination in metalworking systems is a critical problem. This study determined the microbial communities in metalworking fluids (MWFs) from two machining shops and investigated the effect of quorum sensing inhibition (QSI) on biofilm growth. In both operations, biofilm-associated and planktonic microbial communities were dominated by Pseudomonadales (60.2–99.7%). Rapid recolonization was observed even after dumping spent MWFs and meticulous cleaning. Using Pseudomonas aeruginosa PAO1 as a model biofilm organism, patulin (40 µM) and furanone C-30 (75 µM) were identified as effective QSI agents. Both agents had a substantially higher efficacy compared to α-amylase (extracellular polymeric substance degrading enzyme) and reduced biofilm formation by 63% and 76%, respectively, in MWF when compared to untreated controls. Reduced production of putatively identified homoserine lactones and quinoline in MWF treated with QS inhibitors support the effect of QSI on biofilm formation. The results highlight the effectiveness of QSI as a potential strategy to eradicate biofilms in MWFs.en_US
dc.description.sponsorshipNational Science Foundation NSF 1635347; MJ Murdock Charitable Trust; National Institute of General Medical Sciences of the National Institutes of Health P20GM103474en_US
dc.identifier.citationOzcan, Safiye S., Markus Dieser, Albert E. Parker, Narayanaganesh Balasubramanian, and Christine M. Foreman. "Quorum sensing inhibition as a promising method to control biofilm growth in metalworking fluids." Journal of Industrial Microbiology & Biotechnology (April 2019): 1-9. DOI:10.1007/s10295-019-02181-7.en_US
dc.identifier.issn1367-5435
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/15515
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.titleQuorum sensing inhibition as a promising method to control biofilm growth in metalworking fluidsen_US
dc.typeArticleen_US
mus.citation.journaltitleJournal of Industrial Microbiology & Biotechnologyen_US
mus.contributor.orcidBalasubramanian, Narayanaganesh|0000-0003-2478-464Xen_US
mus.data.thumbpage20en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.1007/s10295-019-02181-7en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentMathematical Sciences.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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