Diurnal Variation, Response to Eccentric Exercise, and Association of Inflammatory Mediators with Muscle Damage Variables
dc.contributor.author | Miles, Mary | |
dc.contributor.author | Andring, J.M. | |
dc.contributor.author | Pearson, Sherri Diane | |
dc.contributor.author | Gordon, L.K. | |
dc.contributor.author | Kasper, C. | |
dc.contributor.author | Depner, Chris M. | |
dc.contributor.author | Kidd, J.R. | |
dc.date.accessioned | 2013-11-08T20:54:24Z | |
dc.date.available | 2013-11-08T20:54:24Z | |
dc.date.issued | 2008 | |
dc.description.abstract | This investigation determined whether inflammatory mediators 1) have diurnal variations, 2) respond to high-force eccentric exercise, and 3) associate with markers of muscle damage after high-force eccentric exercise. College-aged men and women (n 51) completed exercise (3 15 maximal eccentric elbow flexor actions using 1 arm) and control conditions in random order. Blood was collected preexercise and 4, 8, 12, 24, 48, and 96 h postexercise. Additional measures included maximal isometric force and midbiceps arm circumference (to detect swelling). Serum and plasma were analyzed for soluble tumor necrosis factor receptor-1 (sTNFR1), IL-6, C-reactive protein, cortisol, and creatine kinase (CK) activity. Relative to the 7:00 AM point in the control condition, diurnal decreases were measured at 12:00 PM and 4:00 PM for IL-6 and at 12:00 PM, 4:00 PM, and 8:00 PM for sTNFR1 and cortisol. sTNFR1, IL-6, CK, swelling, and soreness were higher in the exercise compared with the control condition. The largest of the inflammatory mediator responses was measured for IL-6 8 h postexercise in the exercise (3.00 3.59 pg/ml) relative to the control condition (1.15 0.99 pg/ml). The IL-6 response (time-matched exercise control concentration) at 8 h associated (r 0.282) with muscle soreness at 24 and 96 h, and the cortisol response at 8 h associated (r 0.285) with swelling at 8, 24, and 96 h. Thus soreness and swelling, but not CK and strength loss, had a low association with the inflammatory response following eccentric exercise. | en_US |
dc.identifier.citation | Miles MP, JM Andring, SD Pearson, LK Gordon, C Kasper, CM Depner, and JR Kidd. Diurnal variation, response to eccentric exercise, and association of inflammatory mediators with muscle damage variables. Journal of Applied Physiology,104(2):451-458, 2008. | en_US |
dc.identifier.uri | https://scholarworks.montana.edu/handle/1/2925 | |
dc.language.iso | en_US | en_US |
dc.publisher | American Physiological Society | en_US |
dc.subject | Health sciences | en_US |
dc.title | Diurnal Variation, Response to Eccentric Exercise, and Association of Inflammatory Mediators with Muscle Damage Variables | en_US |
dc.type | Article | en_US |
mus.citation.extentfirstpage | 451 | |
mus.citation.extentlastpage | 458 | |
mus.citation.issue | 2 | |
mus.citation.journaltitle | Journal of Applied Physiology | |
mus.citation.volume | 104 | |
mus.identifier.category | Health & Medical Sciences | |
mus.relation.college | College of Education, Health & Human Development | |
mus.relation.college | College of Education, Health & Human Development | |
mus.relation.department | Health & Human Development. | en_US |
mus.relation.university | Montana State University - Bozeman | en_US |
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