Health & Human Development

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The Department of Health and Human Development is a group of dedicated faculty and staff whose interests, while diverse, center on one central theme: human beings. HHD works to help individuals from early childhood to mature adults though teaching, research, and service programs in both the public and private sectors.

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Start date: 1998End date: 1999

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    Leukocyte Adhesion Molecule Expression During Intense Resistance Exercise
    (American Physiological Society, 1998) Miles, Mary; Leach, S.K.; Kraemer, W.J.; Dohi, K.; Bush, J.A.; Mastro, A.M.
    We hypothesized that expression of L-selectin and very late antigen-4 (VLA-4) integrin adhesion molecules would influence cell type-specific redistribution during exercise. Women subjects performed six sets of 10-repetition maximum squats. L-selectin and VLA-4 integrin were measured by using flow cytometry pre- and postexercise on peripheral blood neutrophils and lymphocytes (n 5 29 subjects) and lymphocyte subsets (n 5 70 subjects), respectively. Neutrophil concentration increased 41.8% (P , 0.001), whereas the percent expressing L-selectin was unchanged (79%). Lymphocyte concentration increased 61.8% (P , 0.001). The percent of T cells expressing L-selectin decreased from 73.5 6 8.9 to 68.2 6 11.4% (P , 0.001); the combined population of natural killer and B cells expressing L-selectin decreased from 80.4 6 22.5 to 62.7 6 25.8% (P , 0.001). VLA-4 integrin was expressed by nearly all lymphocytes both pre- and postexercise. The proportional decrease in L-selectin positive cells could have resulted from 1) shedding of L-selectin, 2) selective entry of L-selectin-negative subsets, or 3) selective removal of L-selectin-positive subsets.
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