Core Protein-Directed Antivirals and Importin β Can Synergistically Disrupt Hepatitis B Virus Capsids
Date
2022-01
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American Society for Microbiology
Abstract
The HBV core, an icosahedral complex of 120 copies of the homodimeric core (capsid) protein with or without packaged nucleic acid, is transported to the host nucleus by its interaction with host importin proteins. Importin-core interaction requires the core protein C-terminal domain, which is inside the capsid, to “flip” to the capsid exterior.
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Keywords
HBV, antiviral, assembly, capsid, karyopherin
Citation
Kim, Christine, Lauren F. Barnes, Christopher J. Schlicksup, Angela J. Patterson, Brian Bothner, Martin F. Jarrold, Che-Yen Joseph Wang, and Adam Zlotnick. "Core Protein-Directed Antivirals and Importin β Can Synergistically Disrupt Hepatitis B Virus Capsids." Journal of virology 96, no. 2 (2022): e01395-21.
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Except where otherwised noted, this item's license is described as copyright American Society for Microbiology 2022